Biological Activity and Antitumor Studies of Some Metal Complexes with O,N,O- Chelating Schiff’s Base Ligand

Author(s) Name:

Abeer A. Faheim^a,  Dalia I. Saleh^b , Amal M. Al-Khudaydi^b,

 ^aChemistry Department, Faculty of Science (Girl’s), Al-Azhar University, Nasr-City, Cairo, Egypt, P.O. Box 11754,

^bChemistry Department, Faculty of Science, Taif University, Saudi Arabia.

Abstract:

New metal complexes of Schiff base ligand derived from isatin and 4-aminoantipyrine (IAAP) with Co(II), Cu(II) and Ce(III) were prepared, and characterized by analytical and different spectroscopic techniques. On the basis of these characterizations, it was revealed that Schiff base ligands acts as a neutral tridentate ONO with octahedral geometry around metal ion. The synthesized Schiff base and its metal complexes were tested for their antibacterial, antifungal, and cytotoxic activities. The activity data show that metal complexes possessed a broad spectrum of activity against some investigated microbial species and potent cytotoxicity effect against growth of colon carcinoma cell (HCT-116) and Mouse Myelogenous leukemia carcinoma (M-NFS-60) compared to (IAAP) ligand. Moreover, the corrosion inhibition of carbon steel in HCl by some metal complexes using weight loss method was tested indicating that the metal complexes can act as corrosion inhibitors.

Key words: Schiff base; complexes;   characterizations ; corrosion inhibition, antimicrobial activity, antitumor cytotoxicity.  

Please cite this article as:

Abeer A. Faheim,  Dalia I. Saleh  and Amal M. Al-Khudaydi,  (2019)  Biological Activity and Antitumor Studies of Some Metal Complexes with O,N,O- Chelating Schiff’s Base Ligand. International Journal of Recent Research and Applied Studies, 6- 4(4), 22-35