Abstract :
Analysis of NMR water proton spin lattice relaxation (T1) with radiopharmaceutical Beta-methyl-p-I-123-iodophenyl-pentacanoic acid (I-123 BMIPP) organ doses in ORNL/MIRD phantom and GSF reference voxel male (RVM) phantom in 12 human organs yield a nice correlation of 0.84 and 0.79 respectively. Further correlation is established between I-123 BMIPP organ doses (Gy/Bq) with reference man organ weight yielding a correlation of 0.85 and 0.77 in 13 human organs in ORNL/MIRD and GSF RVM phantoms. This methodology provides a new approach to measure organ doses of therapeutic and diagnostic radiopharmaceutical in nuclear medicine by measuring the T1 of the organ or using organ weight.
Author Name : Syed Farooq Akber
Keywords: MIRD, BMIPP, Organ weight, T1, Radiation dose.
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