Anti diabetic activity, Anticancer activity and α-amylase enzyme inhibitory effect of Tetrakis (4-aminopyridine- kN1) di chloride copper (II) monohydrate, [CuCl2(C5H6N2)4].H2O

Author(s) Names:

M.Renuga devi, A.Sinthiya, S.Lingeswari, P.Lalitha, M. Koperuncholan

Abstract:

The functional group of the crystal Tetrakis (4-aminopyridine- _kN¹) di chloride copper (II) monohydrate, [CuCl₂(C₅H₆N₂)₄].H₂O complex confirmed by FTIR spectrum. The crystal taken in the form of solution and subjected to biological activity test. Its particle size and Zeta potential calculated. It exhibit good zone of inhibition against bacteria Escherichia coli, Pseudomonas putida, Bacillus Badius, Pseudomonas aeruginosa and Staphylococcus aureus. Antibacterial activity of this complex showed 90% reduction in the Colony-forming Unit CFU and for this same concentration it displayed efficient radical scavenging activity compared to the standard antioxidant (Ascorbic acid). This complex show good anti diabetic property  and Anti cancer activity. The molecular docking results show that this complex has greater binding affinity towards  α-amylase enzyme when compared to HIV (human immunodeficiency virus) protease, COX (Cyclo-oxgenase) and EGFR (Epidermal growth factor Receptor)  enzyme through N_{(amino radical of 4-aminopyridine)}-H…O_{(carboxylic group of enzyme)} hydrogen bonding.

 Keywords:

Copper complex of 4-aminopyridine, α-amylase enzymes, antidiabetic activity, anticancer activity, Molecular docking.

Please cite this article as:

M.Renuga devi, A.Sinthiya, S.Lingeswari, P.Lalitha, M. Koperuncholan (2020). Anti diabetic activity, Anticancer activity and α-amylase enzyme inhibitory effect of Tetrakis (4-aminopyridine- _kN¹) di chloride copper (II) monohydrate, [CuCl₂(C₅H₆N₂)₄].H₂O. International Journal of Recent Research and Applied Studies, 7, 6(2), 11-18.