Author(s) Name:
Binthiya Suny Gabriel1&Dr Tessamma Thomas2
1Research Scholar, Department of Electronics, Cochin University of Science and Technology, Kochi, Kerala, India 682022
2Research Supervisor, Retd. Professor,Department of Electronics, Cochin University of Science and Technology, Kochi, Kerala, India 682022
Abstract:
Breast cancer is a sophisticated disease and a detailed research into the mechanisms underlying the development of tumour, has paved a way towards the characterization of Transcription Factors (TFs). The application of TFs in the breast cancer therapeutics is an area of interest to several researchers. A way to bring out the regulatory relations between TF and its target genes, messenger RNA (mRNA), is to measure the changes in the expression of the gene in response to TF perturbation. TFs are considered to regulate the expression of more than 20 per cent of the entire gene in the mammalian cells. The mRNAs with the greatest change in the expression levels are not necessarily the ones that are most relevant. However, differentially expressed TFs have greater importance in a biological context in relation to the progression of cancer than TFs that target and modulate just a few mRNA transcripts. In this paper, a new technique for analysing this nature of modulation by TF, has been developed, which determines the binding regions of TFs to the mRNAs using a normalised correlation method. The analysis includes 30 breast cancer specific mRNAs and the various TFs that target each mRNAs. The new correlation method identifies the binding regions of all the TFs and the results obtained are comparable with those obtained for the STFT method.
KEYWORDS; mRNA, Breast Cancer, TF, Binding Region, Normalised Correlation.
Please cite this article as
Binthiya Suny Gabriel & Dr Tessamma Thomas (2021) Comparison of Correlation Method with Modified STFT Method for Breast Cancer Specific mRNA-TF Interaction analysis . International Journal of Recent Research and Applied Studies, 8- 8(4), 15-20
Leave a Reply