Abstract :
At present situation in the pharma field, only some numbers of effective drugs are exist. The emergence of multidrug resistant pathogens must be necessary of novel antibiotics. Currently opportunistic pathogens like V.cholerae, S.typhi were resistant against vancomycin, ampicillin, methicillin, tetracycline etc. Marine resources are hopeful environment for new drug discoveries. Especially, marine microbes are played main role on discovery of antibiotics. In this study, marine sediment samples were used for isolation of marine bacterial colonies from Nagapattinam coast. Distinct colonies noted as DC and DN were isolated using nutrient agar and actinomycetes isolation agar and morphology, biochemical properties were performed. Antimicrobial susceptibility test were done against common clinical pathogens and multidrug resistant (MDR) pathogens. Among isolated colonies, DC5 has better bactericidal activity. It showed average results against all opportunistic pathogens. Used ethyl acetate extraction, it has more functional groups and analysed by Fourier Transformed Infrared spectroscopy (FT-IR).
Author Name : Thiyagarajamoorthy Dhinesh Kumar, Murugaiah Santhosh Gokul, Thanamegam Kaviarasan, Santhaseelan Henciya, Rathinam Arthur James
Keywords: Drugs, Vancomycin, Methicillin, MDR, FT-IR.
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