A Review Conductometric Measurement of Interaction of Anionic Surfactant with Phenothazine Drug at Room Temperature

Author(s) name:

Adesuyi, A.T,  Aboluwoye, C.O, Olaseni, S.E & Borokini, F.B

Abstract

Prometizine Hydrochloride-PMZ is a first generation HI receptor antagonist, Antihistimine, and anti- emetic medication that can also have a strong sedative effect[11]. The incidence and severity of drug interractions are on the rise as more medications are brought to market. For a drug to get to its target soon as possible, the critical  micelle concentration- cmc must be appreciably low. However, most drug’s cmc are higher which generally leads  to wastage of fund; It then means more drugs will be taken in to the biological system for effective delivery. This review aimed at the  interaction of amphilphile with anionic surfactant which may usually helps in bringing down cmc as at when required. Conductometric measurement  gives detailed picture of the interraction between Promazine[PMZ] and Sodiumduodecylsulphonate [SDS] using conductometric titration. Solid Promethazine hydrochloride is an odourless white faint yellow which can medically act sedatives, for combating hay fever and migraines, and  to reduce nervousness and agitation.

 Keywords:

Amphiphilic, Surfactant, Critical Micelle Concentration.

Please cite this article as:

Adesuyi, A.T,  Aboluwoye, C.O, Olaseni, S.E & Borokini, F.B (2020). A  Review Conductometric Measurement of Interaction of Anionic Surfactant with Phenothazine Drug at Room Temperature. International Journal of Recent Research and Applied Studies, 7, 2(2), 5-11.