Author(s) Name:
Obidike Ikechukwu Johnlouis & Egbuonu Anthony Cemaluk
Abstract:
Utilization of food waste could improve food supply hence; lessen the environmental hazards caused by these wastes. This study investigated some biochemical effect of cocoa (theobroma cacao) pod ethanol extract on renal histo-morphology and function in monosodium glutamate (MSG)- intoxicated rats, using standard protocols. To evaluate the biochemical response, 24 male Wistar rats (weight range 80 – 101g) were grouped into six (n=4). Group 1, the positive control received feed and water while the group 2 (negative control) received MSG alone. The group 3 (extract control) received the extract at 300mg/kg body weight while the group 4 received MSG and 150mg extract. Group 5 received MSG and 300mg of extract while group 6 received MSG and 500mg of the extract. There was a significant (p<0.05) decrease in Urea and creatinine concentration characterized by negative change relative to MSG group. There was also a significant (p<0.05) increase in RBC in all the treatment groups (groups 4, 5, and 6) compared to the MSG group. The histopathological examination of the kidney indicated a clear central vein with no congestion at 150mg (groups 4), 300mg (5 respectively) in relation to the MSG group seemingly supporting the serum chemistry results on the ameliorative effects of the different extract concentrations on the toxicity induced by MSG. Thus, extract of cocoa pod which is a food waste has ameliorative effect on MSG induced renal assault.
Keywords:
Bio-Chemical, Cocoa, Monosodium Glutamate, Intoxicated Rats.
Please cite this article as:
Obidike Ikechukwu Johnlouis & Egbuonu Anthony Cemaluk (2020). Some Biochemical Effect of Cocoa (Theobroma Cacao) Pod Ethanol Extract on Renal Histo-Morphology and Function in Monosodium Glutamate (MSG)- Intoxicated Rats. International Journal of Recent Research and Applied Studies, 7, 5(3), 17-28.
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